Miyoshi twice fired Japan into the lead only for Uruguay to level through a penalty from Luis Suarez and a second-half header from Jose Gimenez.

The draw means Japan have an outside chance of reaching the quarter-finals from Group C, with one game remaining against Ecuador.

Carlos Queiroz's team became the first side into the knock-out rounds after following up Saturday's 2-0 win over Argentina with another victory over the Asian champions.

It was a deserved success but one that had looked likely to elude the 2001 champions as they toiled against a Qatar side that defended stoically and held on grimly for more than 85 minutes.

Qatar, who will host the next World Cup in 2022, may now need to beat Lionel Messi's Argentina in their final Group B match if they are to reach the last eight.

Vargas, who plays for Mexico club Tigres UANL, netted twice in the second half as defending champions Chile gradually overpowered a skillful but limited Japan, who are playing in the South American showpiece as one of two invited teams from Asia.

An Oscar Cardozo penalty and a stunning Derlis Gonzalez strike gave the South Americans a 2-0 lead in Rio de Janeiro but goals from Almoez Ali and Khoukhi in the final quarter snatched a share of the Group B spoils for the tournament debutants.

Earlier in the day, Spanish giants Real announced the 18-year-old was joining the record 13-time European champions from FC Tokyo, to play for their B team next season.

"Being called the Japanese Messi is an honour and makes me proud, but I'm still not at his level and I prefer to concentrate on my abilities and strengths," said Kubo from Japan's Copa America base in Sao Paulo.

"We have decided to invite ... to participate in our competitions the current Asian confederation champions and the previous ones," said Alejandro Dominguez, the president of South American football's governing body.

The announcement came the day before the 2019 competition kicks off in Sao Paulo with hosts Brazil taking on Bolivia.

Qatar, the 2022 World Cup hosts, are participating in the Copa America as guests for the first time this year and line up in Group B alongside 14-time former winners Argentina, Colombia and Paraguay.

The 18-year-old joins from FC Tokyo and will play for Madrid's B team, Castilla, next season.

"Takefusa Kubo will join Castilla next season," a Real Madrid statement read. "He is one of the most promising young players in world football, an attacking midfielder with excellent technique and great vision for the game."